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Sensing mechanism also holds for single-stranded probes, thus enabling the detection of E. coli single-strand binding protein (SSBP). (Top) The Faradaic current arising from such a single-stranded probe is significantly reduced upon binding with this target. (Bottom) Of note, because the single-stranded probe wraps around the protein target, different length probes (20, 40, and 70 bases) give rise to different responses upon protein binding. Shown are responses to 80 nM of SSBP.
