Table 3.

Comparison of demographics and exposures of 30 Acanthamoeba keratitis cases and 39 clinic-matched controls wearing soft contact lenses.

	Matched Case-Control Pairs					Univariate Analysis
	Cases:		Controls:				95% CI
	Total N = 30	%	Total n = 39	%	Total n = 69	Conditional OR*			Chi-square p-value
Demographics
Sex
Male	16	53.33	18	46.15	69	1.04	0.26	4.13	0.953
Female	14	46.67	21	53.86
Missing	0		0
Age
13 – <33	21	70.00	20	51.28	69		matching variable
33 – <53	5	16.67	11	28.21
53 – 74	4	13.33	8	20.51
Missing	0		0
General Health:
Good, fair, poor	8	26.67	18	46.15	69	0.36	0.10	13.57	0.132
Excellent	22	73.33	21	53.85
Missing	0		0
Smoking Status:
Yes	3	10.00	5	12.82	69	1.08	0.17	6.70	0.938
No	27	90.00	34	87.18
Missing	0		0
Contact Lens Use and Hygiene
Use Contact Lens:
>10 times per month	27	90.00	34	87.18	69	2.43	0.26	126.00	0.778
≤ 10 times per month	3	10.00	5	12.82
Missing	0		0
Silicone hydrogel contact lens use:
Yes	0	0.00	6	28.57		1.04	0.89	2.11	0.812
No	25	100.00	15	71.43	46
Missing	5		19
Sleep with contact lens:
≥ 1 time per month	7	24.14	11	28.21	68	0.42	0.09	2.07	0.286
0 times per month	22	75.86	28	71.79
Missing	1		0
Actual contact lens replacement:
Quarterly or less frequently	7	25.93	17	50.00	63	0.418	0.13	1.43	0.164
More frequently than quarterly	20	74.07	17	50.00
Missing	3		5
Age of case at replacement:
>3 months	21	70.00	21	53.85	68	2.34	0.74	7.41	0.149
≤ 3 months	8	30.00	18	46.15
Missing	1		0
Reuse solution:
>5 times per month	17	58.62	10	25.64	68	3.19	1.10	9.27	0.033
0–5 times per month	12	41.38	29	74.36
Missing	1		0
Contact Lens Solutions
Solution use
AMO Complete MoisturePlus product	16	55.17	4	10.53
B&L Renu Products	5	17.24	13	34.21
Alcon Optifree Products	0	0.00	7	18.42
Hydrogen peroxide disinfectants	0	0.00	4	10.53
Generic	4	13.79	3	7.89
Other Soft Contact Lens Solutions	0	0.00	1	2.63
Multiple Soft Contact Lens solutions	4	13.79	6	15.79
AMO Complete MoisturePlus + additional soft contact lens solution	3 of 4		1 of 6
B&L Renu + additional soft contact lens solution	1 of 4		5 of 6
Alcon Optifree + additional soft contact lens solution	1 of 4		5 of 6
Missing	1		1
Dichotomous solution use
Exclusive use of AMO Complete MoisturePlus	16	55.17	4	10.53	67	17.76	2.23	141.22	0.007
All other soft contact lens solutions use†	13	44.83	34	89.47
Missing	1		1
Multipurpose Solution Use
Yes	29	100.00	32	84.21	67	4.91	0.64	∞	0.139
No	0	0.00	6	15.79
Missing	1		1
Hydrogen Peroxide Use
Yes	0	0.00	5	13.16	67	0.179	0	1.54	0.125
No	29	100.0	33	86.84
Missing	1		1
Saline Use
Yes	2	6.90	5	13.16	67	0.58	0.01	8.36	p > 0.999
No	27	93.10	33	86.64
Missing	1		1
Daily Cleaner Use
Yes	1	3.45	6	15.79	67	0.33	0.06	4.15	0.625
No	28	96.55	32	84.21
Missing	1		1
Enzyme Use
Yes	1	3.45	3	7.89	67	1.41	0.02	117.66	p > 0.999
No	28	96.55	35	92.11
Missing	1		1
Lens-Handling Hygiene
Rub lenses when cleaning
≤ 10 times per month	20	76.67	20	53.85	65	2.54	0.61	10.56	0.200
>10 times per month	7	23.33	18	46.15
Missing	3		1
Wet hands while cleaning lenses
>1 time per month	21	72.41	31	79.49	68	0.60	0.17	2.15	0.428
0 times per month	8	27.59	8	20.51
Missing	1		0
Rinse case with tap water
>1 time per month	22	75.86	28	73.68	67	1.07	0.32	3.57	0.918
0 times per month	7	24.14	10	26.32
Missing	1		1
Shower with lenses
>5 times per month	21	70.00	21	53.85	69	2.91	0.77	11.06	0.117
0–5 times per month	9	30.00	18	46.15
Missing	0		0

^*Exact conditional logistic regression used when necessary

^†Includes single use of all other products and also use of two or more products, including Complete MoisturePlus