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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Cancer Cell. 2006 Dec;10(6):459–472. doi: 10.1016/j.ccr.2006.10.003

Figure 1.

Figure 1

Loss of neurofibromin induces senescence in human fibroblasts, but immortalizes mouse embryonic fibroblasts

A: Growth curve and immunoblot of normal human IMR90 fibroblasts infected with a control lentiral vector (V), or lentiviruses expressing NF1 shRNAs. At each cell passage cells were re-plated and SA-β-gal activity and morphology was assessed (bottom panels).

B: SA-β-gal activity in response to p120RasGAP knock-down.

C: Proliferative properties of wild-type and NF1KD MEFs. Doxorubicin (DR) treatment (0.2 μg/ml for 18 hours) was used at passage 21, to assess p53 status.