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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Cancer Cell. 2006 Dec;10(6):459–472. doi: 10.1016/j.ccr.2006.10.003

Figure 2.

Figure 2

Senescence triggered by neurofibromin-deficiency requires Rb and p53 pathways

A: Immunoblots demonstrating that p53 and Rb are activated in response to NF1-loss.

B: NF1 was inactivated in cells previously infected with an empty vector (pMKO.1), LgT, a dominant-negative p53 (p53DD), or a Large T Δ234-444 mutant. SA-β-gal-expression is shown.