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. Author manuscript; available in PMC: 2009 Jun 8.

Published in final edited form as: Clin Chim Acta. 2007 Jun 23;385(1-2):48–60. doi: 10.1016/j.cca.2007.06.011

MALDI-TOF MS mass spectra for modified peptides found in digests of glycated HSA but absent in digests of normal HSA. The mass spectrum in (b) is for a modified peptide with a mass of 971.50 Da that originates from the 535–541 region of HSA and represents a fructosyl-lysine modification (ΔM, 162.05 Da). The mass spectrum in (d) is for a modified peptide with a mass of 1130.56 Da that corresponds to the 286–294 region of HSA and represents a N_ε-carboxymethyl-lysine modification (ΔM, 58.01 Da). The mass spectra in (a) and (c) show the absence of these modified peptides in digests of normal HSA.

MALDI-TOF MS mass spectra for modified peptides found in digests of glycated HSA but absent in digests of normal HSA. The mass spectrum in (b) is for a modified peptide with a mass of 971.50 Da that originates from the 535–541 region of HSA and represents a fructosyl-lysine modification (ΔM, 162.05 Da). The mass spectrum in (d) is for a modified peptide with a mass of 1130.56 Da that corresponds to the 286–294 region of HSA and represents a N_ε-carboxymethyl-lysine modification (ΔM, 58.01 Da). The mass spectra in (a) and (c) show the absence of these modified peptides in digests of normal HSA.