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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Periodontol. 2008 Nov;79(11):2190–2199. doi: 10.1902/jop.2008.080210

Table 1.

Effects of glycation by MG of type I collagen and fibronectin on the morphologies of gingival and periodontal ligament fibroblasts after 12 hours

Collagen* Collagen-MG

Cell Length Area Perimeter Shape
factor§
Cell Length Area Perimeter Shape
factor


Human Gingival Fibroblast
165.2** 6631.6 453.1 0.422 128.0‡‡ 3079.7‡‡ 362.5‡‡ 0.321‡‡
(32.8) (2392.9) (97.7) (0.145) (42.4) (1779.9) (130.3) (0.135)
Periodontal Ligament Fibroblast
215.0 12253.5 672.1 0.364 211.1 6197.3‡‡ 510.9‡‡ 0.320††
(48.6) (5422.6) (163.9) (0.160) (59.2) (2684.2) (139.9) (0.132)


Fibronectin* Fibronectin-MG

Cell length Area Perimeter Shape factor Cell length Area Perimeter Shape factor


Human Gingival Fibroblast
182.4 7963.8 527.2 0.368 134.0‡‡ 4952.8‡‡ 346.6‡‡ 0.520‡‡
(41.6) (4470.0) (142.1) (0.126) (31.4) (1954.4) (68.5) (0.138)
Periodontal Ligament Fibroblast
200.3 13629.0 572.4 0.527 174.9‡‡ 6587.0‡‡ 590.6 0.275‡‡
(24.6) (3614.8) (76.3) (0.130) (56.2) (3665.0) (223.6) (0.141)
*

rat tail type I collagen and human plasma fibronectin

type I collagen and fibronectin were glycated with methylglyoxal as detailed under Materials and Methods

units of measurement presented are cell length and perimeter (μm), area (μm2)

§

shape factor coefficient reflects (area/perimeter2) × 4π.

**

presented are means and SD (in parentheses) for 150 measured cells per condition.

††

Significant (P < 0.01)

‡‡

Significant (P < 0.001)

(Mann-Whitney U test).