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Voxel-by-voxel comparison map of gray matter volume (A) and density (B) in bipolar adolescents with and without co-morbid marijuana abuse, overlaid on a T1-weighted three-dimensional anatomic image. Statistically significant differences in gray matter volume were defined as p ≤ 0.001, with a cluster size of 200 (red, abusers > nonabusers; blue, nonabusers > abusers).
