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. Author manuscript; available in PMC: 2010 Jul 7.
Published in final edited form as: Neuroscience. 2009 Apr 5;161(3):915–925. doi: 10.1016/j.neuroscience.2009.03.072

Figure 2.

Figure 2

Analyses of cochlear pathology. 2A: A typical example of hair cells with apoptotic features 10 min post-exposure. The specimen was stained with propidium iodide. Arrows point to the outer hair cells with very condensed nuclei. 2B: TUNEL staining in a cochlea with a focal hair cell lesion 4 h post-exposure. Note that hair cells having condensed nuclei also exhibit TUNEL fluorescence, confirming that these cells were dying by apoptosis. 2C: Comparison of the numbers of apoptotic hair cells quantified at the three post-exposure times. Note that the number of apoptotic cells is significantly reduced at 7 days post-exposure. Values plotted are the mean (n=5 for each time point) + SD. 2D: The cochleogram showing the percentage of missing cells measured 7 days post-exposure. Missing hair cells are more evident in the middle and basal portions of the organ of Corti. Values plotted are the mean (n=5) + SD.