Rat thoracic aorta pulse wave velocity (PWV) reported in m/s measured from saline (A)-, beta-aminopropionitrile (BAPN; B)-, cystamine (C)-, and pyridoxamine (D)-treated groups. Post-hindlimb unweighting (post-HLU) measures are compared in E, where S = saline, B = BAPN, C = cystamine, and P = pyridoxamine. Paired measures are illustrated with a connecting line. Pre- and post-HLU measures were made before and after the 7 day HLU period. *P < 0.001, **P < 0.001; n = 6 for each group.