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Values are means ± SE; n = 8–10 rats/group. ACh-induced dilation in young (A) and old (B) SFA in the absence or presence of Nω-nitro-l-arginine (l-NNA; 300 μM) to inhibit nitric oxide synthase. B, baseline diameter before the 1st dose of ACh. Dose-response curve significantly different from 1Sed, 2Ex, 3Sed + l-NNA, and 4Ex + l-NNA, P ≤ 0.05.
