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Values are means ± SE; n = 8–10 rats/group. ACh-induced dilation in young (A) and old (B) SFA in the absence or presence of l-NNA (300 μM) and indomethacin (Indo; 5 μM) to inhibit nitric oxide synthase and cyclooxygenase. B, baseline diameter before the 1st dose of ACh. Dose-response curve significantly different from 1Sed and 2Ex, P ≤ 0.05.
