Table 2.
Parameter | Con | l-NNA | Indo | l-NNA + Indo |
---|---|---|---|---|
Maximal diameter, μm | ||||
Young Sed | 199±5 | 193±7 | 195±11 | 180±13 |
Young Ex | 196±12 | 178±16 | 191±12 | 184±15 |
Old Sed | 170±8 | 173±10 | 174±17 | 187±12 |
Old Ex | 200±10 | 194±8 | 171±11 | 171±10 |
Initial tone, % | ||||
Young Sed | 48.6±4.1 | 73.9±2.8a,c,d | 45.3±6.9b | 57.6±4.5b |
Young Ex | 40.1±4.3 | 60.4±4.7a,c | 34.4±4.1b,d | 54.7±6.1a,c |
Old Sed | 44.0±6.4 | 67.5±5.2a,c,d | 32.0±4.0b | 45.6±4.9b |
Old Ex | 46.4±3.9 | 55.8±4.9c,d | 33.4±2.3a,b,d | 44.1±2.7b,c |
Values are means ± SE; n = 8–10 rats/group. Con, control; l-NNA, Nω-nitro-l-arginine; Indo, indomethacin. Significantly different from
Con,
l-NNA,
Indo,
l-NNA+ Indo, P ≤ 0.05.