Table 1.

Cardiorenal and humoral function

	Baseline	Δ with BNP 8-32	Δ with BNP 1-32	P value†
Hemodynamic function
Heart rate, beats/min	123±12	+7±3*	+17±5*	0.15
Right atrial pressure, mmHg	1.3±0.4	−0.5±0.2*	−0.8±0.3*	0.39
Pulmonary artery pressure, mmHg	12.6±0.7	−1.2±0.7	−0.5±0.4	0.33
Pulmonary capillary wedge pressure, mmHg	4.2±0.6	−0.9±0.3*	−1.5±0.4*	0.31
Cardiac output, l/min	4.0±0.2	−0.4±0.3	−0.1±0.1	0.44
Systemic vascular resistance, mmHg·l−1·min	33±2	+1.5±2.0	+0.5±0.8	0.67
Renal vascular resistance, mmHg·l−1·min	432±37	−55±23*	−81±20*	0.18
Renal function
Glomerular filtration rate, ml/min	47±6	+9±3*	+10±5	0.67
Urinary potassium excretion, μEq/min	23±3	+28±4*	+48±4*	0.02
Humoral function
Hematocrit, %	40±1	+0.9±0.9	+3.2±0.4*	0.09
Atrial natriuretic peptide, pg/ml	11±1	+5±1*	+5±1*	0.74
Plasma renin activity, ng·ml−1·h−1	9.9±1.6	−4.5±0.9*	−2.2±0.7*	0.10
Angiotensin II, pg/ml	12.5±2.9	−4.3±2.5	−0.4±0.9	0.13
Aldosterone, ng/dl	10.5±2.4	+4.9±6.2	−2.6±1.2	0.22
Plasma sodium, mmol/l	145±1	+0.7±1.0	+2.1±0.9	0.34
Plasma potassium, mmol/l	4.1±0.1	−0.0±0.1	−0.0±0.0	0.91

Values are expressed as means ± SE. Baseline denotes levels during the first clearance before any peptide infusion

^*P < 0.05 vs. respective preinfusion level.

^†P value for comparison of changes from respective preinfusion levels induced by BNP 8-32 vs. BNP 1-32. BNP, B-type natriuretic peptide; Δ, change from preinfusion level.