Fig. 7.

Effect of changes in nuclear distribution on the rate constant for nuclear processes. A diffusion distance of 14.5 μm (observed radius of myonuclear domain; A) is compared with a distance of 300 μm (hypothetical case with only SS nuclei in an adult fiber; B). If the population of IM nuclei did not increase during light fiber hypertrophic growth there would be a three-order-of-magnitude-smaller rate constant that could be attained at any given effectiveness factor (η), for any diffusion coefficient.