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. 2009 Mar 25;296(6):R1855–R1867. doi: 10.1152/ajpregu.00076.2009

Table 1.

Influence of mitochondrial distribution and subdivision of dark fibers on η, average nondimensional O2 and ATP concentrations, k1, and k2 for small and large fibers

Length, μm SS fraction, % k1, s−1 k2, mM−1 ·s−1 Avg Nondimensional O2 Concn Avg Nondimensional ATP Concn η ATP Turnover Rate, mM/min
Light fiber
40 48 0.0009 0.86 0.94 0.86 0.99 0.47
40 0 0.0009 0.86 0.90 0.86 0.99 0.46
300 88 0.005 0.186 0.55 0.16 0.77 0.47
300 0 0.005 0.186 0.20 0.05 0.26 0.16
Dark fiber
17.5 75 0.005 1.10 0.96 0.61 0.99 1.84
17.5 0 0.005 1.10 0.92 0.59 0.98 1.80
300 75 0.012 14.9 0.065 0.25 0.32 1.84
300 0 0.012 14.9 0.027 0.13 0.17 0.98

SS, subsarcolemma; k1, ATPase rate constant; k2, oxidative phosphorylation rate constant. Data are based on experimentally determined diffusion path lengths and phosphagen recovery rates (6, 24, 30, 38). Output was obtained at the lowest values of k1 that would satisfy the observed rate, which maximized η. ATP turnover rate is fixed in the observed case (SS mitochondrial fraction =48, 88, or 75%), and k1 and k2 values from these observed cases are used in the hypothetical cases with only intermyofibrillar mitochondria (SS mitochondrial fraction = 0).