Fig. 10.

The contraction and intracellular Ca²⁺ signaling of Ca²⁺-permeabilized rat airway SMCs in response to Y-27632, a Rho kinase inhibitor, and GF-109203X, a PKC inhibitor. A: a representative trace showing the relaxant effect of 10 μM Y-27632 on the Ca²⁺-induced contraction in the Ca²⁺-permeabilized rat airway SMCs. This relaxant response was not associated with significant change in [Ca²⁺]_i (B). In comparison, 2 μM GF-109203X (C) had little effect on the Ca²⁺-permeabilized rat airway contraction induced by 1.3 mM Ca²⁺.