Table 3. Associations between selected autoimmune conditions and histologic subtypes of non-Hodgkin lymphoma (NHL), with exclusions of time intervals prior to diagnosis/selection.
| Excluded time interval prior to NHL diagnosis/control selection | |||
|---|---|---|---|
| NHL subtype and autoimmune condition | 1 year excluded | 2 years excluded | 5 years excluded |
| OR (95% CI)* | OR (95% CI)* | OR (95% CI)* | |
| Diffuse large B-cell lymphoma | |||
| Rheumatoid arthritis | 1.4 (1.2-1.5) | 1.4 (1.2-1.6) | 1.5 (1.3-1.8) |
| Sjögren syndrome | 2.0 (1.5-2.8) | 2.1 (1.5-3.0) | 1.6 (0.9-2.7) |
| Systemic lupus erythematosus | 1.4 (1.0-2.0) | 1.5 (1.0-2.2) | 1.6 (1.0-2.7) |
| Sarcoidosis | 2.0 (1.2-3.3) | 1.7 (0.9-3.1) | 1.7 (0.7-3.9) |
| Systemic sclerosis | 2.0 (1.1-3.6) | 1.7 (0.9-3.3) | 1.7 (0.8-3.9) |
| Autoimmune hemolytic anemia | 3.3 (1.7-6.3) | 2.6 (1.2-6.0) | 3.6 (1.2-10) |
| Aplastic anemia | 1.9 (1.1-3.3) | 2.0 (1.0-3.7) | 1.1 (0.3-3.5) |
| Multiple sclerosis | 0.4 (0.2-0.9) | 0.5 (0.2-1.0) | 0.3 (0.1-1.1) |
| T-cell non-Hodgkin lymphoma | |||
| Rheumatoid arthritis | 1.5 (1.1-1.8) | 1.3 (1.0-1.7) | 1.6 (1.1-2.2) |
| Systemic lupus erythematosus | 2.4 (1.3-4.4) | 2.0 (1.0-4.1) | 2.5 (1.0-6.2) |
| Autoimmune hemolytic anemia | 9.7 (4.3-22) | 13 (5.6-30) | 21 (7.4-61) |
| Aplastic anemia | 2.8 (1.0-7.8) | 1.9 (0.5-7.6) | 3.9 (0.9-16) |
| Psoriasis | 3.1 (2.5-4.0) | 2.8 (2.2-3.7) | 2.8 (1.9-4.0) |
| Pemphigus | 5.9 (1.4-25) | 4.0 (0.5-30) | 9.1 (1.2-68) |
| Discoid lupus erythematosus | 4.4 (2.3-8.4) | 3.4 (1.6-7.3) | 4.6 (1.9-12) |
| Celiac disease | 5.9 (2.4-14) | 8.0 (3.2-20) | 7.0 (1.8-26) |
| Ulcerative colitis | 2.0 (1.2-3.3) | 1.9 (1.1-3.4) | 1.5 (0.6-3.6) |
| Follicular lymphoma | |||
| Rheumatoid arthritis | 1.3 (1.1-1.5) | 1.3 (1.1-1.5) | 1.4 (1.1-1.8) |
| Autoimmune hemolytic anemia | 3.4 (1.4-8.2) | 3.7 (1.4-9.7) | 4.9 (1.3-19) |
| Aplastic anaemia | 2.4 (1.1-5.2) | 1.8 (0.7-5.1) | 1.0 (0.1-7.2) |
| Marginal zone lymphoma | |||
| Sjögren syndrome | 6.6 (4.6-9.5) | 5.3 (3.5-8.2) | 6.7 (3.9-11) |
| Systemic lupus erythematosus | 2.8 (1.7-4.7) | 2.9 (1.7-4.9) | 1.5 (0.6-4.1) |
| Autoimmune hemolytic anemia | 7.4 (3.1-17) | 4.8 (1.4-16) | 6.3 (1.4-29) |
| Celiac disease | 3.5 (1.3-9.8) | 3.7 (1.1-12) | 2.3 (0.3-18) |
| Pernicious anemia | 1.4 (1.0-1.8) | 1.3 (1.0-1.8) | 0.9 (0.5-1.5) |
| Chronic lymphocytic leukemia† | |||
| Autoimmune hemolytic anemia | 8.7 (5.5-13) | 9.5 (5.7-16) | 9.6 (4.4-21) |
Associations significant at the p<0.05 level are underlined.
*
Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for age (67-69, 70-74, 75-79, 80-84 and 85-99 years), gender, selection year (1993-1996, 1997-1999, 2000-2001, 2002), race (white, non-white), and number of physician claims (0-20, 21-57, 58-127, ≥128).
†
Includes small lymphocytic lymphom