Skip to main content
. Author manuscript; available in PMC: 2009 Aug 21.
Published in final edited form as: Org Lett. 2008 Jul 19;10(16):3485–3488. doi: 10.1021/ol801264u

Table 1.

Selection of base additive.a

graphic file with name nihms-108650-f0004.jpg
entry base additive equiv isolated yield (%)
1 Et3N 1.2 18
2 pyridine 1.2 65
3 ethyl nicotinate 1.2 51
4 2-bromopyridine 1.2 74
5 2-fluoropyridine 1.2 90
6 3-chloropyridine 1.2 79
7 2-chloropyridine 1.2 95
8 2-chloropyridine 0 43
9 2-chloropyridine 2.0 91
a

Reaction conditions: Tf2O (1.1 equiv), CH2Cl2, 45 °C, 2 h.