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. Author manuscript; available in PMC: 2010 Feb 23.
Published in final edited form as: Brain Res. 2008 Dec 7;1256:85–91. doi: 10.1016/j.brainres.2008.11.086

Figure 3. PTK/ZK activates ERK in vivo.

Figure 3

A) Representative western blots showing VEGFR2 (Tyr1054/1059) and AKT (Ser473) phosphorylation following intrahippocampal infusion of 1μl of either 5μM PTK/787 or vehicle. B) Summary results showing that PTK/ZK does not significantly alter VEGF or AKT phosphorylation in vivo. C) Representative western blots showing ERK (Thr202Tyr204) phosphorylation following intrahippocampal infusion of 1μl of either 5μM PTK/787 or vehicle. D) Summary results showing that intrahippocampal infusion of PTK/ZK significantly increases phospho-ERK (both p44 and p42) immunoreactivity compared to the vehicle-infused contralateral hippocampus. No change was observed in total ERK levels. p-p42, phospho-p42 ERK; p-p44, phosphor-p44 ERK; *, P ≤ 0.05 by two-tailed t-test.