. 2009 May 19;10:43. doi: 10.1186/1471-2350-10-43

Table 1.

Demographic and clinical characteristics by case-control status and validation study population.

	Genome-wide association			Validation study

Characteristics	Case (N = 101)	Control (N = 101)	P*	Caucasians (N = 704)	African Americans (N = 1467)
Age, years	59.1 ± 9.1	60.3 ± 9.3	0.34	60.7 ± 8.34	50.8 ± 11.0
Females, %	66.3	66.3	1.00	48.9	64.4
Diabetic, %	19.8	12.9	0.18	15.8	22.8
Weight, kg^†	90.1 (70.9 – 114.4)	79.6 (64.2 – 98.7)	0.0001	85.5 ± 17.8	89.9 ± 21.5
Height, cm	164.6 ± 8.0	169.0 ± 8.7	0.0002	168.9 ± 9.1	167.3 ± 9.1
Body mass index, kg/m^2†	33.4 (26.7 – 41.8)	27.9 (23.3 – 33.5)	< 0.0001	29.9 ± 5.5	32.2 ± 7.5
Percentage of body fat^‡	39.3 ± 8.9	36.0 ± 8.2	0.012	35.3 ± 8.6	39.9 ± 9.5
Systolic blood pressure, mm Hg	135.5 ± 20.8	126.1 ± 15.7	0.0003	126.8 ± 20.2	132.1 ± 22.5
Diastolic blood pressure, mm Hg	70.9 ± 12.5	71.0 ± 10.2	0.90	70.1 ± 10.6	75.2 ± 11.7
Pulse pressure, mm Hg	64.7 ± 16.2	55.1 ± 13.7	< 0.0001	56.7 ± 16.2	56.9 ± 16.7
Postural SBP change, mm Hg	-1.32 ± 14.7	-0.91 ± 15.0	0.85	-2.55 ± 14.8	1.63 ± 14.2
Hypertension status
Normal BP, %	0.0	0.0	-	22.9	13.5
Mild hypertension, %	42.6	57.4	-	35.2	37.4
Severe hypertension, %	57.4	42.6	-	41.9	49.1
Antihypertensive drugs, N	1.43 ± 0.84	1.35 ± 0.71	0.42	1.38 ± 0.80	1.35 ± 0.92
LV mass, g	214.5 ± 32.8	130.3 ± 21.8	< 0.0001	171.7 ± 40.5	178.1 ± 49.8
LV mass/body surface area, g/m²	108.9 ± 15.0	68.0 ± 9.0	< 0.0001	87.6 ± 17.3	89.9 ± 22.7
LV mass/height^2.7, g/m^2.7	56.2 ± 6.3	31.4 ± 3.9	< 0.0001	41.6 ± 8.66	44.4 ± 12.1
Urinary albumin:creatinine ratio^†	6.87 (1.93 – 24.4)	3.11 (0.58 – 16.6)	0.0002	3.74 (0.92 – 15.2)	7.24 (1.27 – 41.3)

*P for comparison of means between cases and controls; ^†Reported as geometric mean (SD range) because natural-log transformed values were compared between cases and controls; ^‡Lukaski equation; SBP = systolic blood pressure