Table 5.
Results (as P values) from the validation study genotyping and association analyses for the African American sample.*
| GWAS Cases and Controls (101 pairs) | African Americans (N = 1467) | ||||||
| SNP | Chr | P | Log(LVMI) | LVH | MAF |
Nearest object |
Distance (Mb) |
| rs409045 | 5p13.3 | 8.47E-07 | 0.096 | 0.16 | 0.33 | RAI14 | 0.028 |
| rs6450415 | 5q11.2 | 6.43E-05 | 0.44 | 0.93 | 0.41 | FLJ35954 | 0.10 |
| rs1833534 | 5q34 | 9.62E-05 | 0.67 | 0.052 | 0.14 | CCNG1 | 0.044 |
| rs6961069 | 7q21 | 7.34E-05 | 0.36 | 0.55 | 0.47 | SEMA3C | 0.040 |
| rs10499859 | 7q21 | 3.27E-06 | 0.65 | 0.69 | 0.30 | CD36 | 0.15 |
| rs4129000 | 12q14.3 | 2.26E-05 | 0.83 | 0.51 | 0.21 | LOC729298 | 0.095 |
| rs4129218 | 12q13.3 | 5.19E-05 | 0.26 | 0.17 | 0.41 | LOC729298 | 0.10 |
| rs1155635 | 13q21.33 | 9.09E-05 | 0.53 | 0.73 | 0.22 | KLHL1 | 0.27 |
| rs238688 | 20p13 | 8.33E-05 | 0.013 | 0.09 | 0.28 | ATRN | Intron |
| rs756529 | 20q13.13 | 9.10E-05 | 0.048 | 0.04 | 0.44 | KCNB1 | Intron |
| rs10483186 | 22q12 | 3.12E-05 | 0.28 | 0.63 | 0.27 | LOC91464 | 0.12 |
*Analysis adjusted for age, sex, weight, systolic blood pressure, and diabetes; Chr = chromosome; GWAS = genome-wide association study; LVMI = left ventricular mass index defined as LV mass/height2.7; LVH = left ventricular hypertrophy defined as LVMI > 47 g/m2.7 in women and > 50 g/m2.7 in men; MAF = Overall frequency of carriers of minor allele (homozygotes + heterozygotes); SNP = single-nucleotide polymorphism