Table 2.
FINRISK N = 1176 |
ATBC N = 1270 |
Sweden N = 195 |
PRIME/N.Ireland N = 251 |
PRIME/France N = 296 |
|||||||
Gene | SNP | Non-cases N = 609 |
Casesb N = 567 |
Non-cases N = 718 |
Cases N = 552 |
Non-cases N = 128 |
Cases N = 67 |
Non-cases N = 135 |
Cases N = 116 |
Non-cases N = 182 |
Cases N = 114 |
IL18R1 | rs1420098 (T/C) | 0.37 | 0.38 | 0.39 | 0.41 | 0.43 | 0.41 | 0.42 | 0.42 | 0.41 | 0.37 |
rs1420096 (T/C) | 0.46 | 0.47 | 0.46 | 0.47 | 0.52 | 0.43 | 0.50 | 0.48 | 0.55 | 0.53 | |
rs11465656 (I/D) | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | 0.02 | 0.04 | 0.06 | 0.05 | 0.03 | |
rs3732127 (G/C) | 0.21 | 0.18 | 0.17 | 0.17 | 0.14 | 0.22* | 0.17 | 0.19 | 0.19 | 0.16 | |
rs11465660 C/A) | 0.10 | 0.10 | 0.12 | 0.12 | 0.13 | 0.13 | 0.11 | 0.07 | 0.07 | 0.07 | |
IL18RAP | rs11465670 (T/C) | 0.09 | 0.09 | 0.11 | 0.12 | 0.11 | 0.16 | 0.13 | 0.15 | 0.13 | 0.13 |
rs4851581 (A/G) | 0.14 | 0.15 | 0.15 | 0.13 | 0.08 | 0.03 | 0.08 | 0.10 | 0.09 | 0.11 | |
rs1420106 (G/A) | 0.18 | 0.20 | 0.20 | 0.19 | 0.21 | 0.19 | 0.20 | 0.18 | 0.22 | 0.28 | |
rs1420105 (C/T) | 0.46 | 0.46 | 0.46 | 0.47 | 0.51 | 0.43 | 0.50 | 0.48 | 0.53 | 0.53 | |
rs11465673 (T/C) | 0.09 | 0.10 | 0.12 | 0.12 | 0.13 | 0.14 | 0.11 | 0.07 | 0.07 | 0.06 | |
rs11465702 (A/G) | 0.19 | 0.16* | 0.15 | 0.14 | 0.12 | 0.16 | 0.14 | 0.14 | 0.13 | 0.11 |
a Allele frequency of the minor allele.
b Cases: CHD and strokes were combined
*: Significant cases/non-cases comparison at p < 0.05