Table 3.

Associations of Friedewald and direct LDL cholesterol with cardiovascular disease events

	Per 1-quintile increase					P for linear trend
	Quintile 1	Quintile 2	Quintile 3	Quintile 4	Quintile 5
Range
Friedewald, fasting	<102.3 mg/dL	102.3–120.6	120.7–137.9	138.0–159.6	>159.6
Direct, fasting	<97.8 mg/dL	97.8–115.5	115.6–132.2	132.3–153.9	>153.9
Direct, nonfasting	<97.8 mg/dL	97.8–115.5	115.6–132.2	132.3–153.9	>153.9
HR (95% CI)
Friedewald, fasting	1.00	1.21 (0.90–1.62)	1.40 (1.06–1.85)	1.65 (1.26–2.16)	1.93 (1.49–2.51)	<0.001
Direct, fasting	1.00	1.31 (0.97–1.77)	1.53 (1.15–2.05)	1.99 (1.51–2.63)	2.11 (1.60–2.78)	<0.001
Direct, nonfasting	1.00	0.96 (0.59–1.55)	1.25 (0.79–1.98)	1.16 (0.73–1.85)	1.20 (0.74–1.93)	0.33
	Per 1-SD increase	Per 10 mg/dL increase	P
HR (95% CI)
Friedewald, fasting	1.22 (1.14–1.30)	1.06 (1.04–1.08)	<0.001
Direct, fasting	1.23 (1.15–1.32)	1.06 (1.04–1.08)	<0.001
Direct, nonfasting	1.03 (0.89–1.18)	1.01 (0.97–1.05)	0.72

HRs and 95% CIs were adjusted for age, randomized treatment assignment, smoking status, menopausal status, postmenopausal hormone use, blood pressure, diabetes, and body mass index. P value for linear trend was obtained using the median value for each quintile. Fasting was defined as ≥ 8 hours from last meal.