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The tetracycline-regulated female-killing system. Expression of tTA is controlled with the female- and fat-body-specific transcription enhancer from the yp1 gene (18). In the absence of tetracycline, tTA binds to tetO and induces expression of the proapoptotic gene hid. The loss of fat body results in female-specific lethality. In the presence of tetracycline, females are fully viable, because the binding of tTA to tetO is inhibited, switching off hid expression.
