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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Chem Commun (Camb). 2008 Aug 13;(39):4792–4794. doi: 10.1039/b809537j

Fig. 2.

Fig. 2

Molecular imaging with a bifunctional MSAP-RGD probe. a) The bifunctional MSAP (Scheme 1) was attached onto the lysine side chain of the cyclo[-RGDfK-] tumor-targeting peptide. b) The reaction between the bifunctional MSAP and the RGD substrate was monitored by RP-HPLC using NBD’s absorbance. c) After complexation with 111InCl3, the bifunctional MSAP-RGD probe was injected into a tumor-bearing mouse and monitored by SPECT-CT. d) Distribution of the probe within the tumor was visualized by immunohistochemistry with an antibody to the NBD hapten and compared to the distribution of CD31 (marker for endothelial cells) and CD11b (marker for monocytes/macrophages)