Fig. 4.

Opportunistic infections and life span. Suppurative conjunctivitis from a (A) 51-week old Rag-1-mutant control mouse and a (B) 38-week old double mutant mouse. The red line outlines the abnormal shape of the face in profile due to the protruding periocular abscess. The red dashed box shows the abscess adjacent to the eye that has broken through the skin. Scale bar: 1 cm. Otitis media from a (C) 21-week old Rag-1-mutant control mouse and a (D) 16-week old double mutant mouse. Scale bar: 100 mm. (E) Life span of Rag-1-mutant control (blue) and double mutant (green) mice. There is no statistically significant difference between these life spans (log-rank test, Kaplan-Meier survival analysis: p=0.213); however, there is a statistically significant difference when considering the last point their curves meet (red arrow) to the end (p=0.017).