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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Jan 15;19(5):1425–1427. doi: 10.1016/j.bmcl.2009.01.031

Figure 2.

Figure 2

Molecular modeling (SYBYL 7.2, GOLD 3.3) of IMPDH complexed with inhibitor 1 (shown in green) and substrate IMP. The inhibitor interferes with the binding of NAD+ with the enzyme.