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Locked nucleic acid in situ hybridization (LNA-ISH) for miR-155 and miR-21 expression in archival IPMN tissues. High magnification photomicrographs of an archival IPMN with robust expression of DIG-labeled miR-155 probe (A) and miR-21 probe (B) within the neoplastic epithelium, consistent with expression of these miRNAs within the neoplasm. In contrast, the scrambled miRNA probe demonstrates complete absence of expression (C). Magnification 40x.
