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. 2000 Jul 11;97(15):8233–8238. doi: 10.1073/pnas.150220297

Figure 6.

Figure 6

Comparison of the SH3-like folds from HIV-1 IN, Sac7d, and Sso7d. (a) α-Carbon overlay of the HIV-1 IN C-terminal domain (magenta), Sac7d (green), and Sso7d (blue) structures demonstrates significant structural similarity. (b) Primary sequence alignment of the IN C-terminal domains from HIV-1, SIV, and RSV, and DNA-binding proteins Sac7d and Sso7d based on secondary structure (HIV-1 IN residue numbering). Secondary structural elements are highlighted. Yellow and green denote the β-strands contributing to the β-sandwich structure of the IN C-terminal domains, Sac7d, and Sso7d. Lowercase lettering indicates residues in IN that are involved in protein–protein interactions, and residues in Sac7d and Sso7d that are involved in protein-DNA interactions. Residues highlighted in cyan are involved in protein–protein contacts in at least two of the molecules.