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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Mar 14;19(9):2509–2513. doi: 10.1016/j.bmcl.2009.03.030

Table 1.

The IC50 values for the inhibition of baboon liver mitochondrial MAO-B by isatin (1) and (E)-styrylisatin analogues (4–5)

IC50 valuea (nM)
1 Isatin 8566 ± 530
4a (E)-5-Styrylisatin 41.7 ± 1.8
4b (E)-5-(3-Chlorostyryl)isatin 20.7 ± 0.6
4c (E)-5-(3-Fluorostyryl)isatin 30.1 ± 4.6
5 (E)-6-Styrylisatin 444 ± 12.2
a

The IC50 values were determined as described previously12 and are expressed as the means ± SEM of duplicate determinations.