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. Author manuscript; available in PMC: 2010 Feb 1.
Published in final edited form as: Mol Immunol. 2008 Oct 25;46(5):917–926. doi: 10.1016/j.molimm.2008.09.005

Fig.1.

Fig.1

The VH gene family usage by human mAbs against V3, CD4bd, CD4i and gp41 compared to control antibodies from healthy individuals. Anti-V3 mAbs preferentially use the VH5 gene family (p<0.0001), represented exclusively by VH5-51 gene segment, while the VH3 gene family use was significantly reduced (p<0.0001). Anti-CD4i mAbs exclusively used the VH1 gene family (p<0.0001) while the anti-gp41 mAbs used the VH1 gene family significantly more (p<0.0001) and used the VH3 gene family significantly less (p<0.0001).