Table 4.
Distributions of the number of putative SHMT1 risk variant genotypes in the combined genotypes of lung cancer cases and cancer-free controls and the association with risk of lung cancer
| Putative SHMT1 risk variants genotype a | Number of subjects (%) |
Pb | Crude OR (95% CI) | Adjusted OR (95% CI)c | |
|---|---|---|---|---|---|
| Patients | Controls | ||||
| Total | 1032 (100.0) | 1145 (100.0) | |||
| 0 | 1 (0.1) | 1 (0.1) | 0.269 | ||
| 1 | 37 (3.6) | 62 (5.4) | |||
| 2 | 498 (48.3) | 573 (50.0) | |||
| 3 | 468 (45.4) | 484 (42.3) | |||
| 4 | 26 (2.5) | 24 (2.1) | |||
| 5 | 2 (0.2) | 1 (0.1) | |||
| 0–1 | 38 (3.7) | 63 (5.5) | 0.056 | 1.00 | 1.00 |
| 2 | 498 (48.3) | 573 (50.0) | 1.44 (0.95–2.19) | 1.39 (0.89–2.18) | |
| 3+ | 496 (48.1) | 509 (44.5) | 1.62 (1.06–2.46) | 1.65 (1.05–2.57) | |
| Ptrend = 0.029 | Ptrend = 0.013 | ||||
| 0–2 | 536 (51.9) | 636 (55.5) | 0.092 | 1.00 | 1.00 |
| 3+ | 496 (48.1) | 509 (44.5) | 1.16 (0.98–1.37) | 1.21 (1.01–1.45) | |
a
Constructed from the combination of dichotomized genotypes as shown in Table 2.
b
Two-sided χ2 test for the difference in the genotype or allele distributions between the cases and the controls.
c
Due to missing data, 932 cases and 1073 controls were analyzed with adjustment for age, sex, smoking status, square root of pack-years smoked, alcohol drinking status, and dietary intake of total folate, vitamin B6, vitamin B12, and methionine in logistic regression models.