Table 5.
Frequency distribution and adjusted ORs and 95% CIs for the putative SHMT1 risk variants genotype stratified by selected variables in the lung cancer patients and controls
| Variables | Number of patients (%) |
Number of controls (%) |
Adjusted OR (95% CI) a |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Total | 0–2 | 3+ | Total | 0–2 | 3+ | 0–2 | 3+ | ||
| Total | 932 | 485 (52.0) | 447 (48.0) | 1073 | 599 (55.8) | 474 (44.2) | 1.00 | 1.21 (1.01–1.45) | |
| Age | ≤61 | 452 | 236 (52.2) | 216 (47.8) | 520 | 291 (56.0) | 229 (44.0) | 1.00 | 1.17 (0.91–1.52) |
| >61 | 480 | 249 (51.9) | 231 (48.1) | 553 | 308 (55.7) | 245 (44.3) | 1.00 | 1.30 (1.01–1.67) | |
| Sex | Female | 436 | 217 (49.8) | 219 (50.2) | 553 | 308 (55.7) | 245 (44.3) | 1.00 | 1.27 (0.98–1.64) |
| Male | 496 | 268 (54.0) | 228 (46.0) | 520 | 291 (56.0) | 229 (44.0) | 1.00 | 1.19 (0.92–1.53) | |
| Smoking status | Never | 156 | 78 (50.0) | 78 (50.0) | 182 | 105 (57.7) | 77 (42.3) | 1.00 | 1.35 (0.87–2.10) |
| Former | 397 | 205 (51.6) | 192 (48.4) | 515 | 283 (54.9) | 232 (45.1) | 1.00 | 1.23 (0.94–1.61) | |
| Current | 379 | 202 (53.3) | 177 (46.7) | 376 | 211 (56.1) | 165 (43.9) | 1.00 | 1.18 (0.87–1.60) | |
| Pack-years smoked | Never | 156 | 78 (50.0) | 78 (50.0) | 182 | 105 (57.7) | 77 (42.3) | 1.00 | 1.35 (0.87–2.10) |
| Light | 199 | 100 (50.2) | 99 (49.7) | 353 | 187 (53.0) | 166 (47.0) | 1.00 | 1.16 (0.81–1.66) | |
| Heavy | 577 | 307 (53.2) | 270 (46.8) | 538 | 307 (57.1) | 231 (42.9) | 1.00 | 1.25 (0.98–1.60) | |
| Alcohol use | Never | 333 | 170 (51.0) | 163 (49.0) | 326 | 186 (57.1) | 140 (42.9) | 1.00 | 1.32 (0.97–1.81) |
| Former | 306 | 167 (54.6) | 139 (45.4) | 267 | 159 (59.5) | 108 (40.5) | 1.00 | 1.25 (0.89–1.75) | |
| Current | 293 | 148 (50.5) | 145 (49.5) | 480 | 254 (52.9) | 226 (47.1) | 1.00 | 1.16 (0.86–1.57) | |
| Total folate intake | High | 388 | 210 (54.1) | 178 (45.9) | 539 | 290 (53.8) | 249 (46.2) | 1.00 | 1.04 (0.79–1.36) |
| Low | 544 | 275 (50.5) | 269 (49.5) | 534 | 309 (57.9) | 225 (42.1) | 1.00 | 1.39 (1.09–1.78) | |
| Vitamin B6 intake | High | 420 | 218 (51.9) | 202 (48.1) | 529 | 297 (56.1) | 232 (43.9) | 1.00 | 1.30 (0.99–1.69) |
| Low | 512 | 267 (52.1) | 245 (47.9) | 544 | 302 (55.5) | 242 (44.5) | 1.00 | 1.17 (0.91–1.49) | |
| Vitamin B12 intake | High | 479 | 260 (54.3) | 219 (45.7) | 534 | 304 (56.9) | 230 (43.1) | 1.00 | 1.20 (0.92–1.55) |
| Low | 453 | 225 (49.7) | 228 (50.3) | 539 | 295 (54.7) | 244 (45.3) | 1.00 | 1.26 (0.98–1.63) | |
| Methionine intake | High | 451 | 236 (52.3) | 215 (47.7) | 538 | 311 (57.8) | 227 (42.2) | 1.00 | 1.32 (1.01–1.71) |
| Low | 481 | 249 (51.8) | 232 (48.2) | 535 | 288 (53.8) | 247 (46.2) | 1.00 | 1.12 (0.87–1.44) | |
a
Adjusted for age, sex, smoking status, square root of pack-years smoked, alcohol drinking status, and dietary intake of total folate, vitamin B6, vitamin B12, and methionine in logistic regression models.