Table 2.
Compound | ortho | meta | para | IC50 (μM) or %inhibition at 1μM | MIC[b] (μg/mL) |
---|---|---|---|---|---|
Triclosan | Cl | --- | Cl | 0.6 ± 0.0 | 3.1 |
55 | --- | --- | --- | 0.5 ± 0.1 | 32 |
3 | --- | --- | OH | 2.6% | >64 |
20 | --- | --- | NH2 | 7.1 ± 1.2 | 12 |
18 | --- | --- | 1.6% | 111 | |
19 | --- | --- | 0% | 111 | |
22 | --- | --- | >12[a] | 4.9 | |
4 | --- | --- | NO2 | 7.2% | 3.3 |
5 | NO2 | --- | --- | 7.7 ± 0.7 | 13.3 |
6 | Cl | --- | NO2 | 0.3 ± 0.0 | <0.1 – 3.1 |
7 | --- | --- | Ph | >6.25 | 1.9 |
32 | --- | --- | 15.5% | >145 | |
33 | --- | --- | 9.9% | 2.3 |
Saturation with inhibitor was not obtained over the concentration range tested. The percent inhibition of BaENR showed a linear response to increasing inhibitor concentrations.
MIC values are against ΔANR B. anthracis.