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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: J Pathol. 2008 Sep;216(1):64–74. doi: 10.1002/path

Figure 2.

Figure 2

(A) Summary of secondary KIT resistance mutations detected by D-HPLC in 27/57 tumour samples from 14 patients with progressing GISTs. Associated primary KIT mutations are indicated in red (exon 11 mutations), yellow (exon 9 mutations) and green (exon 13 mutations). (B) Summary of secondary KIT resistance mutations detected by AS–PCR only ( Inline graphic) or detected by both AS–PCR and D-HPLC (●) in 18 tumour samples. Associated primary KIT mutations are indicated in red (exon 11 mutations), yellow (exon 9 mutations) and green (exon 13 mutations)