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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Curr Opin Chem Biol. 2007 Nov 9;11(6):620–625. doi: 10.1016/j.cbpa.2007.09.018

Figure 2.

Figure 2

Fluorescent probes for detection of NO. (a) Probes based on the o-phenylenediamine scaffold give highly fluorescent triazole products upon reaction with nitric oxide in the presence of oxygen. Diaminofluorescein-2 (DAF-2), Diaminorhodamine-4 (DAR-4), Diaminobenzene-BODIPY (DAMBO), DAMBO-4,4-diOMe (DAMBOO), and diaminocyanine (DAC) are representative examples using this switch. (b) Cu(II) complexes of fluorescein derivatives, such as Cu-FL, allow for the direct detection of NO by release of the highly fluorescent nitrosylated FL ligand (FL-NO) upon reduction of Cu(II).