Skip to main content
. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: J Mol Biol. 2007 Aug 22;373(4):990–1005. doi: 10.1016/j.jmb.2007.08.038

Figure 9. Docking model showing the interactions of I79 of gankyrin with the active site of CDK6.

Figure 9

(A) Docking model of the putative gankyrin/CDK6 complex. This model was constructed by superimposing the first four ARs of gankyrin (ribbon diagram, green) onto P16 (ribbon diagram, golden) in the crystal structure of the P16/CDK6 complex15 (PDB ID: 1BI7; CDK6 is shown in solid-filled diagram). Since no structure of CDK4 is available, crystal structure of CDK6, a close homologue of CDK4, is used in this modeling. H66 and D84 of P16, as well as L62 and I79 of gankyrin are highlighted. Surface residues of CDK6 with positive and negative charges are shown in red and blue, respectively, in the solid-filled diagram. The active site of CDK6 is framed and analyzed in (B). (B) Interactions between D84 of P16 (corresponding to I79) and the active site of CDK6. P16 is in golden, and gankyrin is in green. Apparently, interactions with the charged surface of R26 in the active site of CDK6 (R24 in CDK4) depend on the negatively charged Asp of P16.