Table 4.
Sensitivity and specificity of the Mdp score and the individual CpG units methylation of genes for diagnosis of prostate cancer
| CpG unit | Paired t-Test (p Value) | Sensitivity (95% Confidence Interval) | Specificity (95% Confidence Interval) |
|---|---|---|---|
| MdpScore | 1.90E-19 | 87.3 (76.50–94.30) | 87.10 (70.17–96.37) |
| RARB2_CpG_10.11 | 6.14E-10 | 90 (73.47–97.89) | 92.59 (75.71–99.09) |
| RARB2_CpG_1 | 1.36E-09 | 87.1 (70.17–96.37) | 89.29 (71.77–97.73) |
| RARB2_CpG_9 | 7.89E-09 | 90 (73.47–97.89) | 88.89 (70.84–97.65) |
| GSTP1_CpG_21 | 1.77E-07 | 88.46 (69.85–97.55) | 87.10 (70.17–96.37) |
| GSTP1_CpG_10 | 1.74E-06 | 92.31 (74.87–99.05) | 93.55 (78.58–99.21) |
| GSTP1_CpG_22 | 1.74E-06 | 92.31 (74.87–99.05) | 93.55 (78.58–99.21) |
| GSTP1_CpG_17.18 | 1.75E-06 | 87.5 (67.64–97.34) | 86.21 (68.34–96.11) |
| PITX2_CpG_31.32 | 1.93E-06 | 77.42 (58.90–90.41) | 79.31 (60.28–92.01) |
| GSTP1_CpG_19 | 2.62E-06 | 92 (73.97–99.02) | 89.66 (72.65–97.81) |
| GSTP1_CpG_8 | 5.81E-06 | 81.48 (61.92–93.70) | 76.67 (57.72–90.07) |
| FLNC_CpG_36.37.38 | 6.47E-06 | 80.65 (62.53–92.55) | 80.00 (61.43–92.29) |
| PITX2_CpG_14 | 7.84E-06 | 70.97 (51.96–85.78) | 73.33 (54.11–87.72) |
| PITX2_CpG_6.7 | 1.21E-05 | 70.97 (51.96–85.78) | 75.86 (56.46–89.70) |
| PITX2_CpG_34 | 1.21E-05 | 70.97 (51.96–85.78) | 75.86 (56.46–89.70) |
| GSTP1_CpG_11 | 1.37E-05 | 84.62 (65.13–95.64) | 83.33 (65.28–94.36) |
| GSTP1_CpG_12.13 | 1.61E-05 | 83.33 (62.62–95.26) | 83.33 (65.28–94.36) |
| PITX2_CpG_26.27 | 2.83E-05 | 67.74 (48.63–83.32) | 68.97 (49.17–84.72) |
CpG units were ranked by t-Test, p value comparing tumor (n = 64), and benign (n = 32) tissues.