Table 2.
Gene pathways with altered expression in autism
| Gene Set | Genes | NES | p-val | q-val |
|---|---|---|---|---|
| NFKBPATHWAY | 22 | 2.10 | 0.0000 | 0.0000 |
| IL1RPATHWAY | 30 | 2.05 | 0.0000 | 0.0000 |
| TOLLPATHWAY | 32 | 2.05 | 0.0000 | 0.0000 |
| NKTPATHWAY | 25 | 2.00 | 0.0000 | 0.0000 |
| INFLAMPATHWAY | 28 | 1.96 | 0.0000 | 0.0000 |
| GSK3PATHWAY | 25 | 1.91 | 0.0000 | 0.0020 |
| TOB1PATHWAY | 16 | 1.87 | 0.0000 | 0.0040 |
| TNFR2PATHWAY | 17 | 1.86 | 0.0000 | 0.0040 |
| CARDIACEGFPATHWAY | 16 | 1.86 | 0.0000 | 0.0040 |
| P38MAPKPATHWAY | 37 | 1.84 | 0.0030 | 0.0050 |
| TIDPATHWAY | 17 | 1.79 | 0.0000 | 0.0120 |
| G1PATHWAY | 24 | 1.76 | 0.0000 | 0.0200 |
| HIVNEFPATHWAY | 54 | 1.73 | 0.0010 | 0.0290 |
| 4-1BBPATHWAY | 16 | 1.73 | 0.0020 | 0.0270 |
| MCALPAINPATHWAY | 23 | 1.70 | 0.0050 | 0.0340 |
| P53HYPOXIAPATHWAY | 18 | 1.69 | 0.0050 | 0.0350 |
| METPATHWAY | 36 | 1.68 | 0.0030 | 0.0360 |
| DEATHPATHWAY | 32 | 1.67 | 0.0060 | 0.0370 |
| ATMPATHWAY | 18 | 1.66 | 0.0160 | 0.0390 |
| IL6PATHWAY | 20 | 1.66 | 0.0130 | 0.0400 |
| RELAPATHWAY | 15 | 1.65 | 0.0060 | 0.0400 |
| ALKPATHWAY | 32 | 1.65 | 0.0060 | 0.0380 |
| NTHIPATHWAY | 20 | 1.65 | 0.0110 | 0.0410 |
| CASPASEPATHWAY | 21 | 1.65 | 0.0100 | 0.0390 |
| DCPATHWAY | 20 | 1.64 | 0.0140 | 0.0400 |
| AKTPATHWAY | 16 | 1.64 | 0.0070 | 0.0400 |
| ECMPATHWAY | 20 | 1.63 | 0.0130 | 0.0400 |
| RACCYCDPATHWAY | 21 | 1.63 | 0.0220 | 0.0400 |
| IL2RBPATHWAY | 33 | 1.61 | 0.0000 | 0.0450 |
| TH1TH2PATHWAY | 16 | 1.61 | 0.0110 | 0.0450 |
| FASPATHWAY | 26 | 1.60 | 0.0190 | 0.0470 |
Microarray gene expression data, subjected to functional pathway analysis with GSEA using BioCarta pathways, identified 31 differentially expressed groups of genes between AUT and CONT samples. The gene pathways are ranked by a net enrichment score (NES). The number of genes in each pathway is depicted in the Genes column. All the differentially expressed pathways reported a q-value based false discovery rate of less than 5% (q<0.05). Note that most of differentially expressed pathways are involved in immune response (shaded).