Skip to main content
. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Neurobiol Dis. 2008 Mar 10;30(3):303–311. doi: 10.1016/j.nbd.2008.01.012

Table 3.

Autistic samples show increased transcriptome variability

# GENE NAME SYMBOL SDAUT SDCONT SDAUT — SDCONT
1 serpin peptidase inhibitor A3 (alpha-1 antiproteinase) SERPINA3 4.21 0.88 3.33
2 hypothetical protein FLJ10847 FLJ10847 3.33 0.04 3.29
3 stratifin* SFN 3.25 0.06 3.19
4 secreted frizzled-related protein 2* SFRP2 3.44 0.29 3.15
5 secretory leukocyte peptidase inhibitor SLPI 3.13 0.07 3.06
6 stratifin* SFN 3.37 0.33 3.04
7 scavenger receptor class A, member 5* SCARA5 3.70 0.66 3.03
8 heat shock 70kDa protein 6* HSPA6 3.27 0.38 2.89
9 secreted frizzled-related protein 2* SFRP2 3.60 0.71 2.88
10 CD44 molecule* CD44 2.88 0.01 2.87
11 heat shock 70kDa protein 6* HSPA6 3.69 0.94 2.75
12 scavenger receptor class A, member 5* SCARA5 3.16 0.47 2.69
13 CD44 molecule* CD44 3.32 0.67 2.65
14 neuronal PAS domain protein 4 NPAS4 3.75 1.16 2.59
15 CD44 molecule* CD44 2.72 0.15 2.58
16 CD44 molecule* CD44 2.68 0.11 2.57
17 guanylate binding protein 2, interferon-inducible GBP2 2.64 0.07 2.57
18 chemokine (C-C motif) ligand 19 CCL19 3.07 0.51 2.56
19 family with sequence similarity 20, member A* FAM20A 2.57 0.01 2.55
20 leptin receptor* LEPR 2.55 0.02 2.53
21 solute carrier family 26 (sulfate transporter), member 2* SLC26A2 2.97 0.45 2.52
22 sine oculis homeobox homolog 2 SIX2 2.57 0.08 2.50
23 serpin peptidase inhibitor, clade H, member 1 SERPINH1 2.81 0.37 2.43
24 family with sequence similarity 20, member A* FAM20A 2.51 0.09 2.42
25 chitinase 3-like 1 (cartilage glycoprotein-39) CHI3L1 2.82 0.41 2.41
26 --- --- 2.38 0.01 2.38
27 thrombospondin, type I, domain containing 4* THSD4 2.86 0.48 2.38
28 superoxide dismutase 2, mitochondrial* SOD2 2.43 0.07 2.35
29 transmembrane protein 30B TMEM30B 2.37 0.03 2.34
30 sine oculis homeobox homolog 1 SIX1 2.40 0.06 2.34
31 leptin receptor* LEPR 2.34 0.01 2.33
32 CD44 molecule* CD44 2.40 0.08 2.32
33 bone morphogenetic protein 5 BMP5 2.34 0.02 2.32
34 thrombospondin, type I, domain containing 4* THSD4 2.74 0.43 2.31
35 chemokine (C-X-C motif) ligand 10 CXCL10 2.31 0.02 2.30
36 Integrin, beta-like 1 (with EGF-like repeat domains) ITGBL1 2.30 0.02 2.28
37 superoxide dismutase 2, mitochondrial* SOD2 2.76 0.48 2.28
38 interleukin 6 (interferon, beta 2) IL6 2.29 0.02 2.26
39 ADAMTS-like 3 ADAMTSL3 2.46 0.20 2.26
40 actin, gamma 2, smooth muscle, enteric ACTG2 2.93 0.68 2.25
41 myosin, heavy polypeptide 11, smooth muscle* MYH11 2.69 0.44 2.25
42 FLJ45224 protein FLJ45224 2.27 0.04 2.24
43 myosin, heavy polypeptide 11, smooth muscle* MYH11 2.24 0.03 2.20
44 platelet-derived growth factor receptor-like PDGFRL 2.23 0.03 2.20
45 ras-related associated with diabetes RRAD 2.24 0.07 2.17
46 bone morphogenetic protein 4 BMP4 2.16 0.01 2.15
47 secreted frizzled-related protein 4 SFRP4 2.16 0.03 2.13
48 solute carrier family 26 (sulfate transporter), member 2* SLC26A2 2.94 0.83 2.11
49 rabaptin, RAB GTPase binding effector protein 1 RABEP1 2.12 0.02 2.11
50 basonuclin 2* BNC2 2.11 0.01 2.10
51 leptin receptor* LEPR 2.14 0.04 2.10
52 basonuclin 2* BNC2 2.12 0.03 2.10
53 selectin E (endothelial adhesion molecule 1) SELE 2.17 0.08 2.09
54 chloride intracellular channel 6 CLIC6 2.34 0.25 2.08
55 ATP-binding cassette, sub-family G, member 2 ABCG2 2.42 0.35 2.08
56 aquaporin 3 AQP3 2.24 0.17 2.07
57 keratin 18 KRT18 2.09 0.02 2.07
58 microsomal glutathione S-transferase 1 MGST1 2.06 0.02 2.04
59 chemokine (C-C motif) ligand 4 CCL4 2.38 0.36 2.03
60 leptin receptor* LEPR 2.35 0.35 2.00
61 regulator of G-protein signalling 16 RGS16 2.14 0.14 2.00
62 BCL2-associated athanogene 3 BAG3 2.55 0.55 2.00
63 CDNA FLJ34964 fis, clone NTONG2004095 --- 0.03 3.03 −3.00

Variance-based analysis was derived from differences in standard deviation (SD) within the CONT and AUT sample groups. Asterisk denotes multiple probesets against the same genes that obtained similar results. Transcripts involved in immune-cytokine responses are highlighted in grey. In the entire microarray dataset we identified 62 transcripts with high expression variability (SDAUT — SDCONT >2) in AUT subjects and only 1 in the CONT subjects. These data suggest significant transcriptome heterogeneity within the diseased subjects.