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Effects of flovoksamine (FLU) and ranitidine (RAN) on indomethacin (IND) induced ulcers in rats.
| Drugs | Dose (mg/kg) |
Number of animals | Ulcer area (mm2) | Antiulcer effect (%) | P |
|---|---|---|---|---|---|
| FLU | 25 | < 0.05 | |||
| + | 6 | 15.3 ± 1.5 | 48.5 | ||
| IND | 25 | ||||
| FLU | 50 | < 0.02 | |||
| + | 6 | 9.7 ± 0.9 | 67.5 | ||
| IND | 25 | ||||
| FLU | 100 | < 0.01 | |||
| + | 6 | 5.3 ± 0.4 | 82.1 | ||
| IND | 25 | ||||
| FLU | 200 | < 0.001 | |||
| + | 6 | 1.2 ± 0.02 | 96.1 | ||
| IND | 25 | ||||
| RAN | 50 | < 0.001 | |||
| + | 6 | 4.0 ± 0.6 | 86.5 | ||
| IND | 25 | ||||
| Indomethacin (Control) | 25 | 6 | 29.7 ± 2.6 | - | - |
