Table 3.
Adjusted OR for cancers at upper, middle and lower third of the esophagus associated with COX-2 -1195G/A polymorphism.
| COX-2 polymorphism | Controls | Location of ESCC | Total cases | ||||
|---|---|---|---|---|---|---|---|
| Upper + Middle | Lower | ||||||
| No. (%) |
No. (%). |
AOR1 (95% CI) |
No. (%). |
AOR1 (95% CI) |
No. (%). |
AOR1 (95% CI) |
|
| GG | 50 (26) |
23 (19) |
1.0 | 16 (28) |
1.0 | 39 (22) |
1.0 |
| AG | 103 (53) |
59 (48) |
1.7 (0.7 – 4.0) |
21 (36) |
0.9 (0.3 – 2.3) |
80 (44) |
1.2 (0.6 – 2.4) |
| AA | 41 (21) |
40 (33) |
2.0 (0.7 – 5.2) |
21 (36) |
2.3 (0.8 – 6.7) |
61 (34) |
2.3 (1.0 – 5.2) |
| p for H-W2 | 0.471 | ||||||
| GG+AG | 153 (79) |
82 (67) |
1.0 | 37 (64) |
1.0 | 119 (66) |
1.0 |
| AA | 41 (21) |
40 (33) |
1.4 (0.7 – 2.9) |
21 (36) |
2.5 (1.0 – 6.1) |
61 (34) |
2.0 (1.1 – 3.9) |
1 Odds ratios were adjusted for the covariates (age, gender, education level, pack-years of cigarette smoking and of betel quid chewing, and drink-years of alcohol drinking) listed in Table 1.
2p value for Hardy-Weinberg equilibrium test.