Table 4.
The effect modification between COX-2 -1195G/A polymorphism and seropositivity of H. pylori on the risk of ESCC at lower third of the esophagus and all cancers
| COX-2 polymorphism | Lower third ESCC cases | Total ESCC cases | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| H. pylori-negative | H. pylori-positive | H. pylori (+) vs. (-) OR ratio (95% CI) | H. pylori-negative | H. pylori-positive | H. pylori (+) vs. (-) OR ratio (95% CI) | |||||
| Cases/Controls | AOR1 (95% CI) | Cases/Controls | AOR1 (95% CI) | Cases/Controls | AOR1 (95% CI) | Cases/Controls | AOR1 (95% CI) | |||
| GG+AG | 20/72 | 1.0 | 17/81 | 1.0 (0.4 – 2.5) |
1.0 (0.4 – 2.5) |
73/72 | 1.0 | 46/81 | 0.7 (0.4 – 1.4) |
0.7 (0.4 – 1.4) |
| AA | 18/20 | 6.9 (2.1 – 22.5) |
3/21 | 0.6 (0.1 – 2.8) |
0.09 (0.02 – 0.47) |
41/20 | 2.9 (1.2 – 7.3) |
20/21 | 0.9 (0.4 – 2.1) |
0.3 (0.1 – 0.9) |
| AA vs. GG+AG OR ratio (95% CI) |
6.9 (2.1 – 22.5) |
0.6 (0.1 – 2.7) |
2.9 (1.2 – 7.3) |
1.2 (0.5 to 3.0) |
||||||
| p for interaction2 | 0.008 | 0.172 | ||||||||
1 Odds ratios were adjusted for the covariates (age, gender, education level, pack-years of cigarette smoking and of betel quid chewing, and drink-years of alcohol drinking) listed in Table 1.
2Interaction was examined with likelihood ratio test for cross-product terms based on a multiplicative model.