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Temporally ordered pattern of e1a binding reprograms host cell gene expression profile. (A) Time course of e1a genome-wide localization in IMR90 fibroblasts. Each row represents the promoter of a gene in 500-bp intervals from -5.5 to +2.5 kb of the transcription start site (TSS). Enrichment Z scores are indicated to the right of each cluster. (B) Relative gene expression changes of the three clusters at 6, 12, and 24 hours after e1a expression (note the scale).
