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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Behav Pharmacol. 2008 Sep;19(5-6):562–565. doi: 10.1097/FBP.0b013e32830dc110

Fig. 1.

Fig. 1

(a) Effect of clozapine (3.0 mg/kg, intraperitoneally) on average prepulse inhibition (PPI) in male dopamine transporter (DAT) wild-type (WT) and knockout (KO) mice. Vehicle-treated DAT KO mice (n=7) showed PPI deficits compared with vehicle-treated DAT WT mice (n=9), **P<0.01. PPI deficits in DAT KO mice were attenuated by clozapine treatment, as indicated by a lack of a significant genotype effect in clozapine-treated mice. (b) Effect of quetiapine (2.5 mg/kg, subcutaneously) on average PPI in male DATWT and KO mice. Vehicle-treated DAT KO mice (n=6) showed PPI deficits compared with vehicle-treated DAT WT mice (n=9), **P<0.01. PPI deficits in DAT KO mice were attenuated by quetiapine treatment, as indicated by a lack of a significant effect of genotype in quetiapine-treated mice and a significant effect of quetiapine in DAT KO mice, #P<0.05. Data were expressed as mean ± SEM.