TABLE 2.

Hemodynamic changes in response to endothelin receptor blockade

			Endothelin-Receptor Blockade
		Baseline	60 min	120 min
Heart rate, beat/min	Before	61 ± 4	60 ± 4	61 ± 4
	After	59 ± 5	58 ± 4	59 ± 5
Brachial SBP, mmHg	Before	130 ± 8	119 ± 8 †	118 ± 6 †
	After	124 ± 6 *	121 ± 5	115 ± 6 †
Brachial DBP, mmHg	Before	77 ± 4	71 ± 4 †	69 ± 4 †
	After	74 ± 4	71 ± 4 †	67 ± 4 †
Brachial MAP, mmHg	Before	98 ± 6	88 ± 5 †	87 ± 5 †
	After	94 ± 5	90 ± 4	89 ± 5
Brachial PP, mmHg	Before	54 ± 5	48 ± 4	48 ± 4
	After	50 ± 4	50 ± 2	48 ± 3
Carotid SBP, mmHg	Before	119 ± 8	108 ± 7 †	108 ± 6 †
	After	114 ± 6 *	110 ± 5	105 ± 6 †
Carotid PP, mmHg	Before	43 ± 5	37 ± 4 †	38 ± 4 †
	After	39 ± 4 *	39 ± 3	38 ± 4 †
Carotid arterial compliance, mm2/mmHg	Before	0.072 ± 0.006	0.089 ± 0.008 †	0.084 ± 0.007 †
	After	0.080 ± 0.008 *	0.080 ± 0.009	0.077 ± 0.006

Data are mean±SEM. SBP, systolib blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PP, pulse pressure.

^*P<0.05 vs before training.

^†P<0.05 vs. baseline.