Table 1.
Demographic Characteristics for the Study Sample.
| PANDAS (n = 67) M (SD) |
HV (n = 98) M (SD) |
|
|---|---|---|
| Age (yrs) | 8.6 (2.0) | 8.9 (2.1) |
| Full-scale IQ | 110.6 (13.8) | 111.5 (12.2) |
| Age of onset (yrs) | 7.4 (2.2) | |
| Time between onset and testing (yrs) | 1.2 (1.3) | |
| CY-BOCS total score | ||
| All PANDAS subjects (n = 63) | 11.6 (10.7) | |
| PANDAS with OCD and OCD + Tic Disorder (n = 38) | 17.0 (9.3) | |
| YGTSS total score | ||
| All PANDAS subjects (n = 62) | 11.9 (9.7) | |
| PANDAS with Tourette syndrome (n = 25) | 16.0 (7.9) | |
| NIMH Depression (n = 65) | 3.2 (2.1) | |
| PANDAS (n = 67) N (%) |
HV (n = 98) N (%) |
|
| Male | 44 (65%) | 70 (71%) |
| Ethnicity | ||
| White, not Hispanic | 66 (98%) | 87 (88%) |
| Asian or Pacific Islander | 1 (1%) | 2 (2%) |
| Black, not Hispanic | 9 (9%) | |
| Primary diagnosis | ||
| OCD | 15 (22%) | |
| Tourette syndrome | 27 (40%) | |
| OCD + tic disorder | 25 (37%) | |
| Comorbid ADHD | 13 (19%) | |
| Comorbid MDD | 3 (4%) | |
| Subjects taking at least one medication1 | 20 (29%) | |
Abbreviations: PANDAS, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infection; HV, healthy volunteer; CY-BOCS, Children's Yale-Brown Obsessive-Compulsive Scale (range: 0–40); YGTSS, Yale Global Tic Severity Scale (range: 0–50); OCD, Obsessive-Compulsive Disorder; TS, Tourette syndrome; NIMH Depression, National Institute of Mental Health Global Depression rating scale (range: 1–15); ADHD, attention deficit/hyperactivity disorder; MDD, Major Depressive Disorder.
1
Some patients were taking more than one medication; see text for details.