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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Comb Chem. 2009;11(1):91–102. doi: 10.1021/cc800092y

Scheme 4.

Scheme 4

Synthetic scheme of the encoded model library using hydrogel TentaGel shell-core bead. Reagents and conditions : (i) 50% TFA/DCM, 30min; (ii) Boc-Lys(Dde)-OH, HOBt, DIC, DMF; (iii) 50% TFA/DCM, 30min; (iv) Boc-Phe(4-NO2)-OH, HOBt, DIC, DMF; (v) 50% TFA/DCM, 30min ; (vi) 96 Boc-Aa1 / Boc-Aa2 HOBt, DIC, DMF; (vii) 20% piperidine / DMF ; (viii) 96 Fmoc-x-OH, HOBt, DIC, DMF; (ix) 20% piperidine / DMF; (x) Fmoc-Scaffold(NO2)-OH {Fmoc-β-D,L-Phe(NO2)-OH}, HOBt, DIC, DMF; (xi) 2M SnCl2 • 2H2O; (xii) R1COOH or R1COCl or R1SO2Cl; (xiii) 2 % hydrazine / DMF; (xiv) R2COOH or R2COCl or R2SO2Cl; (xv) TFA: phenol: water: TIS (88:5:5:2, v/v %), 30min.