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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: Biochemistry. 2009 May 12;48(18):3894–3903. doi: 10.1021/bi900107m

Figure 2.

Figure 2

The orientation of different willardiines in the GluR2 S1S2 binding site is illustrated. The residues in Lobe 1 were aligned. The positions of HW (red; 1mqj), BrW (green, 1mqh) and FW (black, 1mqi) are superimposable. However, the positions of IW (blue, 1mqg) varies within the same crystal. IW is the lowest efficacy of the four partial agonists. UBP277 (yellow) and UBP282 (cyan) move even further down the binding pocket than IW and make contact with Lobe 2 through the substituents in the 2 position.