TABLE 1.
Total Sample: Main Effects of Years of Education, Age, Sex, Alcohol Use Disorders and COMT Val158Met on WAIS-R Subscale Scores
| WAIS-R subscale | Yrs Ed | Age | Sex | AUD | COMT Val158Met | G × Yrs Ed | Df | Total Var |
|---|---|---|---|---|---|---|---|---|
| Inf | F = 30 | F = 36 | F = 30 | F = 4.3 | F = 5.0 | |||
| P < 0.0001 | P < 0.0001 | P < 0.0001 | - | P = 0.014 | P = 0.007 | 7 | 0.35 | |
| *F = 9.1 | *F = 10.7 | |||||||
| *P = 0.003 | *P = 0.001 | 5 | ||||||
|
| ||||||||
| Dsp | F = 7 | F = 6 | F = 4.6 | |||||
| P = 0.009 | P = 0.014 | - | - | - | P = 0.011 | 6 | 0.14 | |
| *F = 7.3 | ||||||||
| *P = 0.008 | 4 | |||||||
|
| ||||||||
| Ar | F = 44 | |||||||
| P < 0.0001 | - | - | - | - | *F = 3.6 | 3 | 0.15 | |
| *P = 0.059 | ||||||||
|
| ||||||||
| Sim | F = 15 | F = 3.0 | ||||||
| P = 0.0001 | - | - | - | - | P = 0.047 | 5 | 0.18 | |
| *F = 6.5 | ||||||||
| *P = 0.011 | 3 | |||||||
|
| ||||||||
| PC | F = 18 | F = 5.0 | F = 5.0 | |||||
| P < 0.0001 | - | - | P = 0.023 | P = 0.006 | - | 4 | 0.10 | |
| *F = 9.6 | ||||||||
| *P = 0.002 | 3 | |||||||
|
| ||||||||
| DSym | F = 27 | F = 55 | F = 2.6 | |||||
| P < 0.0001 | - | P < 0.0001 | - | P = 0.074 | - | 4 | 0.22 | |
| *F = 2.8 | ||||||||
| *P = 0.098 | 3 | |||||||
|
| ||||||||
| BD | F = 8.6 | F = 3.3 | F = 3.3 | F = 5.5 | ||||
| P = 0.0036 | - | P = 0.071 | P = 0.069 | - | P = 0.005 | 7 | ||
| *F = 11.1 | 0.13 | |||||||
| *P = 0.001 | 5 | |||||||
ANOVA P values ≤ 0.10 are given here. Val/Val, n = 168; Val/Met, n = 134; Met/Met, n = 26, total N = 328.
G × Yrs Ed =interaction effects of COMT Val158Met × Yrs Ed on test scores. Df = degrees of freedom; Var = variance.
Results are given for main and G × Yrs Ed effects for the 3 COMT Val158Met genotypes.
Inf = Information; Dsp = Digit Span; Ar = Arithmetic; Sim = Similarities; PC = Picture Completion; DSym = Digit Symbol; BD = Block Design
*
Results are for COMT Val/Val vs [Val/Met + Met/Met].